CHEN LABORATORY
Bacterial adaptation and Antibody function
CHEN LABORATORY
Bacterial adaptation and Antibody function
xinhaichen@szbl.ac.cn
Education
2011-2015 Ph.D. Sun Yat-sen University, Molecular Biology & Biochemistry, China.
2008-2011 M.S. Fujian Agricultural and Forest University, Molecular Biology & Biochemistry, China.
2004-2008 B.S. Fujian Agricultural and Forest University, Bioinformatics, China.
Dr. Xinhai Chen received his PhD degree from the Sun Yat-sen University at 2015 and then pursued the post-doctoral training in the Missiakas-Schneewind Lab in the Department of Microbiology at the University of Chicago. Dr. Chen has been engaging the bacterial adaptation and anti-bacterial immunity for more than 10 years. He identified a critical activity for complement linked to defined glycosylation pattern of mAbs, engineered candicate mAbs further to enhance complement-mediated opsonophagocytic activity toward Staphylococcus aureus and to improve the half-life of antibodies, as well as compared the contribution of antibody isotypes for the clearance of S. aureus.
Work Experience
2022 - Present Junior Principal Investigator, Institute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China
2020 - 2022 Research Professional, Deptartment of Microbiology, The University of Chicago | Chicago, IL, USA
2016 - 2020 Post-Doctoral Researcher, Deptartment of Microbiology, The University of Chicago, Chicago, IL, USA
2015 - 2016 Associate research fellow, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China
Publications
1) M Bobrovskyy, X Chen, D Missiakas. The Type 7b Secretion System of S. aureus and Its Role in Colonization and Systemic Infection. Infect Immun. 2023, e0001523.
2) X Chen, H Gula, T Pius, C Ou, M Gomozkova, LX Wang, O Schneewind, D Missiakas. Immunoglobulin G subclasses confer protection against Staphylococcus aureus bloodstream dissemination through distinct mechanisms in mouse models. PNAS, 2023, 120(14): e2220765120.
3) L Fan, Z Pan, X Liao, Y Zhong, J Guo, R Pang, X Chen, G Ye, Y Su. Uracil restores susceptibility of methicillin-resistant Staphylococcus aureus to aminoglycosides through metabolic reprogramming. Front Pharmacol, 2023;14: 1133685.
4) J Ye, X Chen (Corresponding author). Current Promising Strategies against Antibiotic-Resistant Bacterial Infections. Antibiotics, 2023; 12(1):67.
5) X Chen, O Schneewind, D Missiakas. Engineered human antibodies for the opsonization and killing of Staphylococcus aureus. PNAS, 2022, 119(4): e2114478119.
6) M Shi, X Chen, Y Sun, HK Kim, O Schneewind, D Missiakas. A Protein A based Staphylococcus aureus vaccine with improved safety. Vaccine, 2021.
7) X Chen, M Shi, X Tong, HK Kim, LX Wang, O Schneewind, D Missiakas. Glycosylation-dependent opsonophagocytic activity of Staphylococcal protein A antibodies. PNAS, 2020, 117(37): 22992-23000.
8) R Pang, H Zhou, Y Huang, Y Su, X Chen (Corresponding author). Inhibition of host arginase activity against staphylococcal bloodstream infection by different metabolites. Front Immunol, 2020, 11, 1639.
9) X Chen, Y Sun, D Missiakas, O Schneewind. Staphylococcus aureus decolonization of mice with monoclonal antibody neutralizing protein A. J Infect Dis, 2019, 219(6):884-888.
10) X Chen, S Liu, B Peng, D Li, Z Cheng, J Zhu, S Zhang, Y Peng, H Li, et al., Exogenous L-valine promotes phagocytosis to kill multidrug-resistant bacterial pathogens. Front Immunol. 2017, 8, 207.
11) X Chen, B Zhang, H Li, X Peng. Myo-inositol improves the host’s ability to eliminate balofloxacinresistant Escherichia coli. Sci Rep, 2015, 5, 10720.
12) Y Wang, S Lin, Q Song, K Li, H Tao, J Huang, X Chen, S Que, H He. Genome-wide identification of heat shock proteins (Hsps) and Hsp interactors in rice: Hsp70s as a case study. BMC genomics, 2014, 15 (1), 1-15.
13) X Chen, S Lin, Q Liu, J Huang, W Zhang, J Lin, Y Wang, Y Ke, H He. Expression and interaction of small heat shock proteins (sHsps) in rice in response to heat stress. Biochim Biophys Acta-Proteins Proteomics, 2014, 1844(4): 818-828.
14) X Chen, W Zhang, B Zhang, J Zhou, Y Wang, Q Yang, Y Ke, H He. Phosphoproteins regulated by heat stress in rice leaves. Proteome Sci, 2011, 9(37): 2-9.
15) X Chen, CG Zhuang, YF He, L Wang, GQ Han, C Chen, HQ He. Photosynthesis, yield, and chemical composition of Tieguanyin tea plants (Camellia sinensis (L.) O. Kuntze) in response to irrigation treatments. Agric Water Manag, 2010, 97 (3), 419-425.
Address：Gaoke International Innovation Center, Guangming District,
Shenzhen, Guangdong Province
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E-mall：xinhaichen@szbl.ac.cn
PI contact person：Xinhai Chen